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Roll over a milestone indicator to view more information.
1997
- Listed on the Toronto Stock Exchange under the name Dimethaid Research Inc., symbol DMX; upon completion an initial public offering which raised proceeds of more than $30 million.
2000
- Opened manufacturing plant in Varennes, Quebec, with the primary mandate to manufacture Pennsaid® and future transdermal products.
- Received Canadian license for manufacturing, packaging and testing pharmaceutical solutions.
- Received successful U.K. manufacturing, packaging and testing report for the Varennes plant covering distribution of Pennsaid® in European Union markets.
- Received final marketing approval for Pennsaid® in the U.K., the first market where Pennsaid® was approved for marketing.
2002
- Entered into a distribution agreement with Italchimici SpA for the exclusive distribution of Pennsaid® in Italy and Malta.
- Completed the acquisition of the remaining 80% of Oxo Chemie AG (“Oxo”) from its founder, Dr Friedrich-Wilhelm Kühne. Oxo (later renamed Dimethaid AG) is a Swiss-based company that developed and commercialized proprietary therapeutic products for treating immune dysfunction.
2003
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Received final marketing approval and launched Pennsaid® in Italy.
- Received final Health Canada approval for Pennsaid®.
- Launched Pennsaid® in Canada using an internal sales force.
- Received marketing approvals for Pennsaid ® in Greece and Portugal.
2004
- Entered into an agreement with Jaba Recordati S.A. for the exclusive distribution of Pennsaid® in Portugal, Madeira and the Azores.
- Entered into a co-promotion agreement with Solvay Pharma Inc. covering the sales and marketing of Pennsaid® in Canada.
- Entered into a distribution agreement with Vianex S.A. for the exclusive distribution of Pennsaid in Greece.
- New Board of Directors elected at the Annual General Meeting.
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New senior management appointed with Dr. Henrich Guntermann named CEO, Daniel H. Chicoine as Chairman of the Board and John C. London as Corporate Secretary.
- Released news of the FDA's non-approvable letter and management's plan to complete the clinical trails necessary to resubmit a Pennsaid® NDA by mid 2006.
2005 (page 1 of 2)
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Entered into a distribution agreement with Healthcare Logistics Limited for the distribution of Pennsaid® in the UK.
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Developed Pennsaid® Plus, a follow on product to Pennsaid®. This formulation is designed to provide users with the efficacy of existing Pennsaid®
with less frequent dosing and increased ease of application.
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Sold Dimethaid Health Care Ltd., a subsidiary of Dimethaid Research Inc. which included the license to market Pennsaid® in Canada to Paladin Labs Inc.
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Commenced a Phase II clinical trial of WF10 in combination with Xeloda® in the treatment of pancreatic cancer at the University of Heidelberg and the National Center for Tumor Diseases.
2005 (page 2 of 2)
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Formed a Scientific Advisory Board to advise on pipeline development.
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Changed the name of the company to Nuvo Research Inc.
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Formed a panel of FDA experts to guide the NDA resubmission for Pennsaid®.
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Reported positive results from the Phase III efficacy/safety trial for Pennsaid®, which met all primary endpoints. The trial confirmed the effectiveness of Pennsaid® in the relief of the signs and symptoms of osteoarthritis of the knee.
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Acquired fqubed, Inc. a San Diego, California based research and development company with proprietary high-throughput screening technology for identifying promising transdermal formulations.
2006
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Entered into an agreement with Paladin Labs Inc., expanding their relationship with respect to the sale and marketing of Pennsaid® in Canada.
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Reported positive results of the Phase III, long-term, open-label safety trial ("Study 112E") for Pennsaid® confirming the safety profile of Pennsaid®.
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Completed an equity financing for gross proceeds of $15 million.
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Licensed Canadian Pennsaid® Plus rights to a subsidiary of Paladin Labs Inc.
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Received an Approvable letter from the U.S. Food and Drug Administration (FDA) for Pennsaid®.
2007
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Determined path to approval for Pennsaid® following discussions with the FDA and commenced the required studies.
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Completed a bought deal equity financing for gross proceeds of $20 million.
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