Technology Publications

 

Multiplexed Molecular Penetration Enhancer (MMPE™) Technology

Multicomponent chemical enhancer formulations for transdermal drug delivery: More is not always better. Arora A, Kisak E, Karande P, Newsam J, Mitragotri S: J. Controlled Release 2010, 144:175-180.

Dependence of the Permeation and Retention of Terbinafine in Human Cadaver Nail, Bovine Hoof, and Shed Snake Skin on Formulation Composition. Hoyer K, Buyuktimkin S, Buyuktimkin N, Singh J, Kisak ET, Newsam JM, King-Smith RD. Presentation at 2009 Annual Meeting of the American Association of Pharmaceutical Scientists, Los Angeles CA, November 8-12 2009.

Examination of the Relationship Between Transdermal Permeation and Drying Time of Various Lidocaine Formulations. Benham D, Buyuktimkin N, Buyuktimkin S, Singh J, Kisak ET, Newsam JM, King-Smith RD. Presentation at 2009 Annual Meeting of the American Association of Pharmaceutical Scientists, Los Angeles CA, November 8-12 2009.

Multiplexed molecular penetration enhancer (MMPE™) systems for increased delivery of diclofenac sodium. Kisak ET, King-Smith RD, Newsam JM, Karande P, Mitragotri S, Singh J. Presentation at Skin and Formulation International Symposium, Versailles France, March 9-10 2009.

Design principles of chemical penetration enhancers for transdermal drug delivery. Karande P, Jain A, Ergun K, Kispersky V, Mitragotri S. Proc. Natl. Acad. Sci 2005, 102:4688-4693.

 

High Throughput Experimentation (HTE) for Formulations Discovery & Development

Using high throughput experimentation (HTE) to develop improved topical NSAID formulations. Kisak ET, Newsam JM, King-Smith RD, Feygin I, Singh J. Presentation at 36th Annual Meeting of the Controlled Release Society, Copenhagen, Denmark, July 18-22 2009.

Accelerated Development of Topical and Transdermal Delivery Systems. King-Smith RD, Newsam JM. In Skin Delivery Systems: Cosmetics, Dermatologicals, and Transdermals, edited by Wille JJ: Blackwell Publishing; 2006:297-308.

Rotary-Drive Dispenser. Feygin I, Newsam JM: US Patent 7,028,726, 2006.

Relationships between Skin's Electrical Impedance and Permeability in the Presence of Chemical Enhancers. Karande P, Jain A, Mitragotri S, J Controlled Release 2006, 110:307-313.

Screening soft materials for their effect on skin barrier function by high throughput experimentation. Newsam JM, King-Smith RD, Jain A, Karande P, Feygin I, Burbaum J, Gowrishankar TR, Sergeeva M, Mitragotri S, J. Materials Chemistry 2005, 15:3061-3068.

Apparatus and Methods for Evaluating the Barrier Properties of a Membrane. Newsam JM, Feygin I, Mitragotri S, King-Smith RD. International application PCT/US2004/024760; WO2005/012549A2, 2004.

Method and apparatus for quasi-continuous and quasi-simultaneous dispensing. Feygin I, Newsam JM. US Patent 6,742,549, 2004.

Fluid-handling systems and components comprising a bladder pump, and methods therefore. Feygin I, Newsam JM. US Patent 6,733,252, 2004.

Discovery of transdermal penetration enhancers by high-throughput screening. Karande P, Jain A, Mitragotri S, Nature Biotechnology 2004, 22:192-197.

Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways. Mitragotri S. J. Controlled Release 2003, 86:69-92.

High Throughput Screening of Transdermal Formulations. Karande P, Mitragotri S. Pharmaceutical Research 2002, 19:655-660.

Combinatorial approaches as a component of high throughput experimentation (HTE) in catalysis research. Newsam JM, Schüth F. Biotechnology and Bioengineering (Combinatorial Chemistry) 1999, 61:203-216.

High Throughput Experimentation: The Role of Computation. Newsam JM, Freeman CM, T. Chemistry Today (Gendai Kagaku) 1998, 1998:31-37.