Nuvo's pipeline of prospective drug candidates for delivery to or through the skin leverages its multiplexed molecular penetration enhancer (MMPE^™) technology. The outermost layer of the skin, the 'stratum corneum', functions as an extremely effective barrier. The stratum corneum is comprised of many different types of molecules. Certain molecules, which Nuvo calls molecular penetration enhancers (MPEs), can interact with molecules in the stratum corneum to enhance its permeability. Nuvo believes that an effective way to enhance the stratum corneum's permeability is to use cocktails of different MPE^™s, which it terms multiplexed molecular penetration enhancers (MMPE^™s).

Nuvo's MMPE^™ technology uses special combinations of MPEs to permeabilize the skin for enhanced delivery of a given drug. Using its HTE technology, the Company has completed hundreds of thousands of measurements on MMPE systems applied to skin in an effort to determine which MMPE^™s are most effective. Nuvo has filed patent applications claiming certain high potential MMPEs and uses of these MMPE^™s. Nuvo is currently using its database of MMPE^™ measurements and its HTE technology to develop topical and transdermal drug candidates.